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Lehninger Principles of Biochemistry
Eighth Edition ©2021 David L. Nelson; Michael M. Cox Formats: Digital & Print
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Authors
-
David L. Nelson
David L. Nelson, born in Fairmont, Minnesota, received his BS inchemistry and biology from St. Olaf College in 1964, and earned his PhD inbiochemistry at Stanford Medical School, under Arthur Kornberg. He was apostdoctoral fellow at the Harvard Medical School with Eugene P. Kennedy,who was one of Albert Lehninger’s first graduate students. Nelson joinedthe faculty of the University of Wisconsin–Madison in 1971 and became afull professor of biochemistry in 1982. For eight years he was Director ofthe Center for Biology Education at the University of Wisconsin–Madison. Hebecame Professor Emeritus in 2013. Nelson’s research focused on the signaltransductions that regulate ciliary motion and exocytosis in the protozoanParamecium. For 43 years he taught (with Mike Cox) an intensive survey ofbiochemistry for advanced biochemistry undergraduates in the life sciences.He has also taught graduate courses on membrane structure and function, aswell as on molecular neurobiology. He has received awards for hisoutstanding teaching, including the Dreyfus Teacher–Scholar Award and theAtwood Distinguished Professorship. In 1991–1992 he was a visitingprofessor of chemistry and biology at Spelman College. Nelson’s second loveis history, and in his dotage he teaches the history of biochemistry andcollects antique scientific instruments.
-
Michael Cox
Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger’s Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and postdoctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992. Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date. For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as a AAAS fellow, and the UW Regents Teaching Excellence Award. Cox’s hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.
Table of Contents
Preface viii
1. The Foundations of Biochemistry
I STRUCTURE AND CATALYSIS
2. Water, the Solvent of Life
3. Amino Acids, Peptides, and Proteins
4. The Three-Dimensional Structure of Proteins
5. Protein Function
6. Enzymes
7. Carbohydrates and Glycobiology
8. Nucleotides and Nucleic Acids
9. DNA-Based Information Technologies
10. Lipids
11. Biological Membranes and Transport
12. Biochemical Signaling
II BIOENERGETICS AND METABOLISM
13. Introduction to Metabolism
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
15. The Metabolism of Glycogen in Animals
16. The Citric Acid Cycle
17. Fatty Acid Catabolism
18. Amino Acid Oxidation and the Production of Urea
19. Oxidative Phosphorylation
20. Photosynthesis and Carbohydrate Synthesis in Plants
21. Lipid Biosynthesis
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
23. Hormonal Regulation and Integration of Mammalian Metabolism
III INFORMATION PATHWAYS
24. Genes and Chromosomes
25. DNA Metabolism
26. RNA Metabolism
27. Protein Metabolism
28. Regulation of Gene Expression
Abbreviated Solutions to Problems
Glossary
Product Updates
Support in Achieve
Lehninger’s Principles of Biochemistry is now supported in Achieve. Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.
New Media Features
- All end-of-chapter questions are available as online assessments in Achieve with hints, targeted feedback, and detailed solutions.
- Skills You Need activities support students with review and practice of prerequisite skills and concepts from chemistry, biology, and math for each biochemistry chapter.
- Instructor Activity Guides give you everything you need to plan and implement activities including interactive media, Clicker questions, and pre- and post-class assessments.
- Interactive Molecular Figures allow students to view and interact with textbook illustrations of protein structures online in interactive 3-D models for a better understanding of their three-dimensional structures.
- Updated and expanded instructor resources and tools.
Tools and Resources to Support Teaching
Course Preparation
- Transition Guide for navigating the changes between editions
- Migration Tool to move your assignments from your previous Sapling Course into your new Achieve course
- Specialized Indices for topics covered throughout the text, including Nutrition and Evolution
- Section management courses allow you to make copies of your course when teaching multiple sections or to serve as a coordinator for other instructors sections.
Class Preparation
- Skills You Need assignments refresh students on content from courses frequently taken as prerequisites
- Standalone slide decks for content, images, and clicker questions that can be used as is or edited.
- Interactive e-book, including assignable sections and chapters.
- LearningCurve Adaptive Quizzing assignments to ensure reading comprehension
Instruction
- Editable all-in-one Lecture Slides that include content, images, clicker questions, multimedia tools, and activities
- Cloud-based iClicker in-class response system
- Instructor Activity Guides, developed with instructors and tied to the principles framework, include both instructor material and assessable student material
- Interactive Metabolic Map and Animated Mechanism Videos, problem-solving videos, and case studies are integrated into Lecture Slides and available as stand-alone resources
Practice and Assessment
- Two editable, curated homework assignments; including an assignment that matches the order and questions in the text and an assignment tied to the principles framework and using questions from the text and other sources
- Question Bank with thousands of additional questions to create an assignment from scratch or add to a curated assignment
- Abbreviated Solutions and Extended Solutions for all text questions
- Case Study assignments
- Test Banks and accompanying software to create tests outside of the Achieve environment.
Reporting and Analytics
- Insights on top learning objectives and assignments to review are surfaced just-in-time (7 day period)
- Detailed reporting by class, individual students, and learning objectives
- Gradebook the synch with iClicker for an easy, all-in-one gradebook
New Text Features
The 8th edition has been fully revised for up-to-date content, as well as to effectively support student study. Written for students learning biochemistry for the first time, the authors have identified and noted fundamental biochemistry principles throughout the text. Content has been streamlined so the text is focused on what is most important and useful to modern students and for future reference!
Organized around principles for better understanding
- This edition provides a new learning path for students, through emphasis on the fundamental principles of biochemistry.
Streamlined for easier navigation
- A new, vibrant design improves navigation through the content.
- Based on extensive user feedback, the authors have carefully trimmed topics and subtopics to emphasize crucial content, resulting in shorter chapters and an overall reduction in book length.
- New or revised figures reflect current research findings.
- Captions have been streamlined throughout.
- Where possible, figures have been simplified, and many figures now have step-by-step annotations, reducing caption length.
- A revised photo program emphasizes context-rich images.
- The end-of-chapter problem sets have been thoroughly revised.
Authors
-
David L. Nelson
David L. Nelson, born in Fairmont, Minnesota, received his BS inchemistry and biology from St. Olaf College in 1964, and earned his PhD inbiochemistry at Stanford Medical School, under Arthur Kornberg. He was apostdoctoral fellow at the Harvard Medical School with Eugene P. Kennedy,who was one of Albert Lehninger’s first graduate students. Nelson joinedthe faculty of the University of Wisconsin–Madison in 1971 and became afull professor of biochemistry in 1982. For eight years he was Director ofthe Center for Biology Education at the University of Wisconsin–Madison. Hebecame Professor Emeritus in 2013. Nelson’s research focused on the signaltransductions that regulate ciliary motion and exocytosis in the protozoanParamecium. For 43 years he taught (with Mike Cox) an intensive survey ofbiochemistry for advanced biochemistry undergraduates in the life sciences.He has also taught graduate courses on membrane structure and function, aswell as on molecular neurobiology. He has received awards for hisoutstanding teaching, including the Dreyfus Teacher–Scholar Award and theAtwood Distinguished Professorship. In 1991–1992 he was a visitingprofessor of chemistry and biology at Spelman College. Nelson’s second loveis history, and in his dotage he teaches the history of biochemistry andcollects antique scientific instruments.
-
Michael Cox
Michael M. Cox was born in Wilmington, Delaware. In his first biochemistry course, the first edition of Lehninger’s Biochemistry was a major influence in refocusing his fascination with biology and inspiring him to pursue a career in biochemistry. After graduate work at Brandeis University with William P. Jencks and postdoctoral work at Stanford with I. Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. He became a full professor of Biochemistry in 1992. Mike Cox has coordinated an active research team at Wisconsin investigating the function and mechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date. For more than three decades, Cox has taught introductory biochemistry to undergraduates and has lectured in a variety of graduate courses. He organized a course on professional responsibility for first-year graduate students and established a systematic program to draw talented biochemistry undergraduates into the laboratory at an early stage of their college career. He has received multiple awards for both his teaching and his research, including the Eli Lilly Award in Biological Chemistry, election as a AAAS fellow, and the UW Regents Teaching Excellence Award. Cox’s hobbies include turning 18 acres of Wisconsin farmland into an arboretum, wine collecting, and assisting in the design of laboratory buildings.
Table of Contents
Preface viii
1. The Foundations of Biochemistry
I STRUCTURE AND CATALYSIS
2. Water, the Solvent of Life
3. Amino Acids, Peptides, and Proteins
4. The Three-Dimensional Structure of Proteins
5. Protein Function
6. Enzymes
7. Carbohydrates and Glycobiology
8. Nucleotides and Nucleic Acids
9. DNA-Based Information Technologies
10. Lipids
11. Biological Membranes and Transport
12. Biochemical Signaling
II BIOENERGETICS AND METABOLISM
13. Introduction to Metabolism
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
15. The Metabolism of Glycogen in Animals
16. The Citric Acid Cycle
17. Fatty Acid Catabolism
18. Amino Acid Oxidation and the Production of Urea
19. Oxidative Phosphorylation
20. Photosynthesis and Carbohydrate Synthesis in Plants
21. Lipid Biosynthesis
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
23. Hormonal Regulation and Integration of Mammalian Metabolism
III INFORMATION PATHWAYS
24. Genes and Chromosomes
25. DNA Metabolism
26. RNA Metabolism
27. Protein Metabolism
28. Regulation of Gene Expression
Abbreviated Solutions to Problems
Glossary
Product Updates
Support in Achieve
Lehninger’s Principles of Biochemistry is now supported in Achieve. Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.
New Media Features
- All end-of-chapter questions are available as online assessments in Achieve with hints, targeted feedback, and detailed solutions.
- Skills You Need activities support students with review and practice of prerequisite skills and concepts from chemistry, biology, and math for each biochemistry chapter.
- Instructor Activity Guides give you everything you need to plan and implement activities including interactive media, Clicker questions, and pre- and post-class assessments.
- Interactive Molecular Figures allow students to view and interact with textbook illustrations of protein structures online in interactive 3-D models for a better understanding of their three-dimensional structures.
- Updated and expanded instructor resources and tools.
Tools and Resources to Support Teaching
Course Preparation
- Transition Guide for navigating the changes between editions
- Migration Tool to move your assignments from your previous Sapling Course into your new Achieve course
- Specialized Indices for topics covered throughout the text, including Nutrition and Evolution
- Section management courses allow you to make copies of your course when teaching multiple sections or to serve as a coordinator for other instructors sections.
Class Preparation
- Skills You Need assignments refresh students on content from courses frequently taken as prerequisites
- Standalone slide decks for content, images, and clicker questions that can be used as is or edited.
- Interactive e-book, including assignable sections and chapters.
- LearningCurve Adaptive Quizzing assignments to ensure reading comprehension
Instruction
- Editable all-in-one Lecture Slides that include content, images, clicker questions, multimedia tools, and activities
- Cloud-based iClicker in-class response system
- Instructor Activity Guides, developed with instructors and tied to the principles framework, include both instructor material and assessable student material
- Interactive Metabolic Map and Animated Mechanism Videos, problem-solving videos, and case studies are integrated into Lecture Slides and available as stand-alone resources
Practice and Assessment
- Two editable, curated homework assignments; including an assignment that matches the order and questions in the text and an assignment tied to the principles framework and using questions from the text and other sources
- Question Bank with thousands of additional questions to create an assignment from scratch or add to a curated assignment
- Abbreviated Solutions and Extended Solutions for all text questions
- Case Study assignments
- Test Banks and accompanying software to create tests outside of the Achieve environment.
Reporting and Analytics
- Insights on top learning objectives and assignments to review are surfaced just-in-time (7 day period)
- Detailed reporting by class, individual students, and learning objectives
- Gradebook the synch with iClicker for an easy, all-in-one gradebook
New Text Features
The 8th edition has been fully revised for up-to-date content, as well as to effectively support student study. Written for students learning biochemistry for the first time, the authors have identified and noted fundamental biochemistry principles throughout the text. Content has been streamlined so the text is focused on what is most important and useful to modern students and for future reference!
Organized around principles for better understanding
- This edition provides a new learning path for students, through emphasis on the fundamental principles of biochemistry.
Streamlined for easier navigation
- A new, vibrant design improves navigation through the content.
- Based on extensive user feedback, the authors have carefully trimmed topics and subtopics to emphasize crucial content, resulting in shorter chapters and an overall reduction in book length.
- New or revised figures reflect current research findings.
- Captions have been streamlined throughout.
- Where possible, figures have been simplified, and many figures now have step-by-step annotations, reducing caption length.
- A revised photo program emphasizes context-rich images.
- The end-of-chapter problem sets have been thoroughly revised.
The authoritative reference, written with a framework for understanding.
Available for the first time in Achieve, the definitive reference text for biochemistry Lehninger Principles of Biochemistry, 8e helps students focus on the most important aspects of biochemistry-- the principles! Dave Nelson, Michael Cox, and new co-author Aaron Hoskins identify the most important principles of biochemistry and direct student attention to these with icons and resources targeted to each principle.
The 8th edition has been fully updated for focus, approachability, and up-to-date content. New and updated end-of-chapter questions -all available in the Achieve problem library with error-specific feedback and thorough solutions. These questions went through a rigorous development process to ensure they were robust, engaging and accurate.
Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry.
Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.
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David L. Nelson; Michael M. Cox | Eighth Edition | ©2021 | ISBN:9781319417420
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Lehninger Principles of Biochemistry
Available for the first time in Achieve, the definitive reference text for biochemistry Lehninger Principles of Biochemistry, 8e helps students focus on the most important aspects of biochemistry-- the principles! Dave Nelson, Michael Cox, and new co-author Aaron Hoskins identify the most important principles of biochemistry and direct student attention to these with icons and resources targeted to each principle.
The 8th edition has been fully updated for focus, approachability, and up-to-date content. New and updated end-of-chapter questions -all available in the Achieve problem library with error-specific feedback and thorough solutions. These questions went through a rigorous development process to ensure they were robust, engaging and accurate.
Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry.
Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.
These materials are owned by Macmillan Learning or its licensors and are protected by United States copyright law. They are being provided solely for evaluation purposes only by instructors who are considering adopting Macmillan Learning's textbooks or online products for use by students in their courses. These materials may not be copied, distributed, sold, shared, posted online, or used, in print or electronic format, except in the limited circumstances set forth in the Macmillan Learning Terms of Use and any other reproduction or distribution is illegal. These materials may not be made publicly available under any circumstances. All other rights reserved. © 2020 Macmillan Learning.
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